(DOWNLOAD) "Whole-Blood Hypercholinemia and Coronary Instability and Thrombosis (Letters) (Letter to the Editor)" by Clinical Chemistry ~ Book PDF Kindle ePub Free
eBook details
- Title: Whole-Blood Hypercholinemia and Coronary Instability and Thrombosis (Letters) (Letter to the Editor)
- Author : Clinical Chemistry
- Release Date : January 01, 2005
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 173 KB
Description
To the Editor: Whole-blood choline (WBCHO) and plasma choline (PLCHO) have been reported to be predictive for cardiac events in patients with suspected acute coronary syndromes (1,2). The differential information of whole-blood vs plasma choline offers insights into the biochemistry and pathophysiology of acute coronary syndromes. A previous study has shown that mean (SD) WBCHO concentrations are significantly increased in patients with non-ST-elevation myocardial infarction [31.1 (18.8) [micro]mol/L] and high-risk unstable angina [47.4 (22.8) [micro]mol/L] compared with patients with noncardiac chest pain [19.4 (6.8) [micro]mol/L] (1) or healthy volunteers [15.8 (9.5) [micro]mol/ L]. For interpretation of WBCHO, a cutoff of 28.2 [micro]mol/L has been proposed (1), which also represents the 90th percentile of a reference population. For PLCHO, the optimum cutoff has not been determined, and 25 [micro]mol/L (99th percentile of a reference population) and lower cutoffs (18.5 [micro]mol/L) have been used for risk stratification. We have selected 3 cases with the constellation of increased WBCHO in combination with low PLCHO to discuss potential pathophysiologic implications. All choline analyses were performed with HPLC-mass spectrometry (1), and choline concentrations were not available for clinical decision-making.
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